Distress Progression as a Risk Factor for Substance use Disorders

Substance use disorders (SUDs) correspond to a range of chronic health conditions defined in the DSM-V as the “recurrent use of alcohol and/or other drugs that causes clinically and functionally significant impairment, such as health problems, disability and failure to meet major responsibilities at work, school, or home” (American Psychiatric Association, 2013). With over 20 million people aged 12 or older in the US that had a SUD related to their use of alcohol or illicit drugs in 2019, substance abuse is a significant public health issue in the US (SAMHSA, 2020). But should SUDs simply be considered as criminal behaviours? Alternatively, are we all at risk of suffering from a SUD at some point in our life? Many scientists argue that SUDs are the result of a pyramid of risk factors that include heredity (i.e., inherited or genetic factors), environment (i.e., environmental and social stressors), and the recurrent use of psychoactive substances (SAMHSA, 2019). Let us examine how heredity and the environment can lead to SUDs.

Source: Image copied from NIDA, 2020

Heredity is one of the main risk factors for developing a SUD or another addictive disorder like gambling, and researchers have now identified several genes that are likely to increase the risk of addiction (Deak & Johnson, 2021). The National Institute on Drug Abuse (NIDA) declared that around 50% of someone’s likelihood to develop an addiction, including SUDs, is based on their genes (National Institute on Drug Abuse, 2019). Genetics is something that none of us has control over, and genetic predispositions could put any individual at risk of developing a SUD in their life. 

However, having a genetic predisposition to SUDs does not necessarily mean that one will actually suffer from a SUD. A person’s health results from interactions between their genes and their environment. Some environmental factors such as an individual’s socio-economic level, access the healthcare, access to substances (illicit drugs or prescription medications), levels of exposure to stress, and the behaviours of people in their social network are known risk factors of SUDs (Mennis et al., 2016; SAMHSA, 2019) 


Stress refers to an individual’s perception and response to harmful or challenging life events. When an individual faces a stressful situation, their brain activates physiological stress responses and adaptive processes to regain homeostasis (Ewald et al., 2019). However, an individual’s ability to cope with stressful events depends on the type of stimulus that triggered distress. This corresponds to the “distress” pyramid, which illustrates how an individual can progress between four states: 1/ no distress (the individual is doing fine), 2/ mental distress (refers to everyday life problems, usually easily overcome by individuals), 3/ mental health problems (severe events in an individual’s life such as a divorce or the death of a close relative, which may cause intense stress and emotions), and 4/ mental health disorders (medically diagnosed psychiatric conditions) (Kutcher, 2021). 

Research showed that early exposure to adverse life events such as the loss of a close relative, parental divorce, domestic violence and sexual abuse are associated with an increased risk of substance abuse (Forster et al., 2018). Exposure to these significant environmental stressors can change the brain’s neuroendocrine hypothalamic-pituitary-adrenal axis with significant conditioning effects on decision-making functions and behaviours. These changes play an essential role in the initiation of substance use and the risk of progression from substance use to SUD (Ewald et al., 2019; SAMHSA, 2019).  


Likewise, chronic exposure to distress in an individual’s personal life or workplace can also influence their brain’s response to stressful events and predict their vulnerability to SUDs (Ewald et al., 2019). There is considerable evidence supporting the role of psychosocial adversity, negative affect, and chronic distress in enhancing the susceptibility to substance use and abuse, the progress from substance use to SUDs, and the risk of relapses (Sinha, 2008; Torres-Berrio et al., 2018). Previous research suggested that cumulative adversity (the cumulative number of stressful events experienced in one’s life) was significantly predictive of substance abuse with a dose-dependent relationship, even after accounting for important control factors such as gender, ethnicity, history of substance use, or socioeconomic status (Mukhara et al., 2018; Sinha, 2008). The more prolonged or repeated the exposure to distress, the higher the risk for persistent dysregulation of an individual’s mental health and the higher the risk of developing SUDs.


In other words, combining high levels of stress or chronic exposure to stress with easy access to substances is the perfect incubator for SUDs. This has a significant implication: Contrary to common belief, many people suffering from SUDs are not “criminals” or “marginalised people”. On the contrary, there are many people who, because of unmanageable stress levels in their personal life or in their workplace, start misusing prescription medication or using illicit drugs as a coping mechanism and progress to a SUD. The key take-home message is that anyone is at risk of suffering from SUDs in their life, especially when exposed to high levels of distress or frequent adverse events.

Because everyone is at risk, community-based interventions are particularly well suited to address SUDs. Interventions that take place in the community can help prevent SUDs and contribute to the treatment of SUDs (Surgeon General, 2016). According to the United Nations Office for Drugs and Crimes, community-based treatment is the most cost-effective SUD treatment approach (UNODC, 2014).


Community-based treatment can facilitate patients’ access to treatment, are usually more affordable for patients and their families, can foster patients’ independence in their natural environment, are less intrusive and less disruptive to daily life as compared to other modalities of treatment, and facilitate the reduction of stigma related to SUDs (UNODC, 2014). 

As previously mentioned, distress progression is one of the main risk factors for SUDs. How can community-based interventions help protect people from the negative consequences associated with chronic distress? Brief interventions aiming at improving an individual’s level of distress tolerance, i.e., “one’s ability to continue engaging in goal-directed behaviour in the face of emotional, cognitive, or physical discomfort”, can easily be delivered in the community by people who are not mental health or addiction specialists (Castillo et al., 2019; Lotan et al., 2013; Russell et al., 2019; Wright et al., 2020).  These interventions on distress tolerance may be helpful both as preventive and treatment levers for SUDs. First, research suggested that greater distress tolerance was associated with a lower risk of developing a SUD but also with better outcomes for SUD treatment, such as increased efficiency of treatment and lower frequency of relapses. On the contrary, lower distress tolerance could be associated with a higher risk of developing SUDs (Bornovalova et al., 2012; Kechter et al., 2021; Reese et al., 2019). Likewise, other stress management and mindfulness brief interventions delivered in the community could help prevent SUDs or be used as part of a therapeutic approach (Chiesa & Serretti, 2014; Nakamura et al., 2015; Reynolds et al., 2020).


To conclude this blog, let us keep this quotation in mind: “No one is immune from addiction; it afflicts people of all ages, races, classes, and professions.”– Patrick J. Kennedy, American politician and mental health activist.


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